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Glucagon-like peptide 1 (GLP-1) receptor agonists use during pregnancy: safety data from regulatory clinical trials

Systemic effects from retatrutide's mechanism: Based on the GLP-1/GIP/glucagon receptor class, potential adverse effects include nausea, vomiting, diarrhoea, reduced appetite, and gastrointestinal disturbance

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Figure 6 3.7 In vitro experiments confirmed that TB001 inhibited PKC and TGF-1/Smad pathways and alleviated EMT process In vitro experiments were carried out using HK-2 cells to validate our findings